Cancer, more than any other human disease, now has a surfeit of potential molecular targets
poised for therapeutic exploitation. Currently, a number of attractive and validated cancer …

There is an increasing number of neurologic disorders found to be associated with loss
and/or dysfunction of the CNS myelin sheath, ranging from the classic demyelinating …

The protein-tyrosine phosphatase PTP1B is a negative regulator of insulin and leptin
signaling and a highly validated therapeutic target for diabetes and obesity. Conventional …

Phosphatases are crucial enzymes in health and disease, but the knowledge of their
biological roles is still limited. Identifying substrates continues to be a great challenge. To …

A further refinement to our previously published “target-bound pharmacophore modeling
approach” is reported herein. Instead of relying on “random” pharmacophores—which is the …

Lymphoid-tyrosine phosphatase (LYP) is mainly expressed in the immune system and plays
an important role in the T-cell receptor (TCR) signaling pathway and tumor immunity. Herein …

Owing to its fundamental roles in cell cycle phases, the cell division cycle 25B (CDC25B)
was broadly considered as potent clinical drug target for cancers. In this study, 3D QSAR …

Redox-cycling compounds can significantly impact biological systems and can be
responsible for activities that range from pathogen virulence and contaminant toxicities, to …

Perineuronal nets (PNNs) have an important physiological role in the retention of learning
by restricting cognitive flexibility. Their deposition peaks after developmental periods of …

Provided are certain novel pyrazine derivatives (1) as SHP2 inhibitors which is shown as
formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More …