Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Cancer initiation and development are increasingly perceived as systems-level phenomena,
where intra-and inter-cellular signaling networks of the ecosystem of cancer and stromal …

Inorganic arsenic is an environmental human carcinogen of several organs including the
urinary tract. RWPE-1 cells are immortalized, non-tumorigenic, human prostate epithelia that …

Mutant KRAS represents one of the most frequently observed oncogenes in NSCLC, yet no
therapies are approved for tumors that express activated KRAS variants. While there is …

RAS signaling is central to many cellular processes and SOS proteins promote RAS
activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1 f/f …

BACKGROUND Mutational activation of Ras genes is established as a prognostic factor for
the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that …

Oncogenic v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-RAS) plays a key role
in the development and maintenance of pancreatic ductal adenocarcinoma (PDAC). The …

Immune checkpoint inhibitors (ICIs), especially those that target programmed cell death
protein 1 (PD-1) and programmed cell death ligand-1 (PD-L1), have been shown to provide …

The largely incomplete and tissue-independent nature of cancer pathways represents a key
limitation to the ability to elucidate mechanistic determinants of cancer phenotypes and to …

MicroRNAs (miRNAs) are a class of noncoding small RNAs (22–25 nucleotides) that
regulate cell proliferation and various cellular functions by interfering with the translation of …