Multifunctional CD40L: pro-and anti-neoplastic activity
A Korniluk, H Kemona, V Dymicka-Piekarska - Tumor Biology, 2014 - Springer
The CD40 ligand is a type I transmembrane protein that belongs to a tumor necrosis factor
(TNF) superfamily. It is present not only on the surface of activated CD4+ T cells, B cells …
(TNF) superfamily. It is present not only on the surface of activated CD4+ T cells, B cells …
Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma
O Fuchs - … & Haematological Disorders-Drug Targets (Formerly …, 2013 - ingentaconnect.com
Multiple myeloma (MM) remains an incurable disease, at least for the big majority of
patients, in spite of the great progress with new drugs in the last years. New treatment …
patients, in spite of the great progress with new drugs in the last years. New treatment …
The relationship between inflammation markers (CRP, IL-6, sCD40L) and colorectal cancer stage, grade, size and location
OM Koper-Lenkiewicz, V Dymicka-Piekarska… - Diagnostics, 2021 - mdpi.com
The aim of the study was the evaluation whether in primary colorectal cancer (CRC) patients
(n= 55): age, sex, TNM classification results, WHO grade, tumor location (proximal colon …
(n= 55): age, sex, TNM classification results, WHO grade, tumor location (proximal colon …
Evaluation of platelet activation marker expression and its correlation with tumorigenesis and tumor progression in patients with gastric cancer
JPA Da Silva, MR Martins… - Journal of Surgical …, 2022 - Wiley Online Library
Abstract Background and Objectives Gastric cancer (GC) remains responsible for over one
million new cases in 2020. Activated platelets express the CD40 ligand (CD40L) and …
million new cases in 2020. Activated platelets express the CD40 ligand (CD40L) and …
Interaction networks converging on immunosuppressive roles of granzyme B: special niches within the tumor microenvironment
W Wang, R Zou, Y Qiu, J Liu, Y Xin, T He… - Frontiers in …, 2021 - frontiersin.org
Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against
ill-defined and/or transformed cells during immunosurveillance. The overall expression of …
ill-defined and/or transformed cells during immunosurveillance. The overall expression of …
Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic …
O Fuchs - Current molecular pharmacology, 2010 - ingentaconnect.com
Nuclear factor-kappaB (NF-κB) upregulates the transcription of proteins that promote cell
survival, stimulate growth, induce angiogenesis and reduce susceptibility to apoptosis. NF …
survival, stimulate growth, induce angiogenesis and reduce susceptibility to apoptosis. NF …
Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced ζ-chain expression in nasopharyngeal carcinoma patients
WK Yip, MA Abdullah, SM Yusoff… - Clinical & Experimental …, 2009 - academic.oup.com
The pathological significance of the mechanisms of tumour immune-evasion and/or
immunosuppression, such as loss of T cell signalling and increase in regulatory T cells …
immunosuppression, such as loss of T cell signalling and increase in regulatory T cells …
CD40 pathway activation reveals dual function for macrophages in human endometrial cancer cell survival and invasion
G Dumas, M Dufresne, É Asselin, J Girouard… - Cancer Immunology …, 2013 - Springer
Reproductive malignancies are a major cause of cancer death in women worldwide. CD40
is a TNF receptor family member, which upon activation may mediate tumor regression …
is a TNF receptor family member, which upon activation may mediate tumor regression …
[HTML][HTML] High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer
Z Herold, M Herold, G Herczeg, A Fodor… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Colorectal cancer (CRC) is often associated with elevated platelet count (>
400× 10 9/L), known as thrombocytosis. The role of CD40 ligand (CD40L), a member of the …
400× 10 9/L), known as thrombocytosis. The role of CD40 ligand (CD40L), a member of the …
Double strike approach for tumor attack: engineering T cells using a CD40L: CD28 chimeric co-stimulatory switch protein for enhanced tumor targeting in adoptive cell …
LF Olguín-Contreras, AN Mendler, G Popowicz… - Frontiers in …, 2021 - frontiersin.org
Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen
receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell …
receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell …