Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Innate immune cell death in neuroinflammation and Alzheimer's disease

Y Rajesh, TD Kanneganti - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

[HTML][HTML] A unique microglia type associated with restricting development of Alzheimer's disease

H Keren-Shaul, A Spinrad, A Weiner… - Cell, 2017 - cell.com
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …

TREM2 maintains microglial metabolic fitness in Alzheimer's disease

TK Ulland, WM Song, SCC Huang, JD Ulrich… - Cell, 2017 - cell.com
Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic
variants of TREM2, a surface receptor required for microglial responses to …

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

D Tejera, D Mercan, JM Sanchez‐Caro… - The EMBO …, 2019 - embopress.org
Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition
of extracellular amyloid‐beta and abnormal tau phosphorylation. Neuroinflammation has …

Brain-resident microglia and blood-borne macrophages orchestrate central nervous system inflammation in neurodegenerative disorders and brain cancer

L Sevenich - Frontiers in immunology, 2018 - frontiersin.org
Inflammation is a hallmark of different central nervous system (CNS) pathologies. It has been
linked to neurodegenerative disorders as well as primary and metastatic brain tumors …

DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

G Shireby, EL Dempster, S Policicchio… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Age-related cerebral small vessel disease and inflammaging

T Li, Y Huang, W Cai, X Chen, X Men, T Lu, A Wu… - Cell death & …, 2020 - nature.com
The continued increase in global life expectancy predicts a rising prevalence of age-related
cerebral small vessel diseases (CSVD), which requires a better understanding of the …

Neuroinflammation and Alzheimer's disease: implications for microglial activation

F Regen, J Hellmann-Regen… - Current Alzheimer …, 2017 - ingentaconnect.com
Background: Microglial activation is a hallmark of neuroinflammation, seen in most acute
and chronic neuropsychiatric conditions. With growing knowledge about microglia functions …

The link between chronic pain and Alzheimer's disease

S Cao, DW Fisher, T Yu, H Dong - Journal of neuroinflammation, 2019 - Springer
Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …