Adhesive structures between cells and with the surrounding matrix are essential for the
development of multicellular organisms. In addition to providing mechanical integrity, they …

Protein tyrosine phosphatases (PTPs) play a crucial role in the regulation of human health
and it is now clear that PTP dysfunction is causal to a variety of human diseases. Research …

Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies
targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications …

The activation of PP5 is essential for a variety of cellular processes, as it participates in a
variety of biological pathways by dephosphorylating substrates. However, activation of PP5 …

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational
modification on serine and threonine residues of cytosolic, nuclear and mitochondrial …

Acute myeloid leukemia (AML) is an aggressive blood cancer with poor prognosis. FMS-like
tyrosine kinase receptor-3 (FLT3) is one of the major oncogenic receptor tyrosine kinases …

Thousand-and-one–amino acid kinase 3 (TAOK3) is a serine and threonine kinase that
belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling …

Hyperactivating mutations in the non-receptor tyrosine phosphatase SHP2 cause Noonan
syndrome (NS). NS is associated with cognitive deficits, but how hyperactivation of SHP2 in …

The tumor suppressor PTEN is essential for early development. Its lipid phosphatase activity
converts PIP3 to PIP2 and antagonizes the PI3K–Akt pathway. In this study, we demonstrate …

Naive T cells respond to antigens by differentiating into effector and regulatory lineages.
Whereas the roles of T cell-intrinsic pathways have been extensively studied, how T cell …