Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical
features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin …

The objective of this review is to present examples of lead compounds identified from
biological material (fungi, plant extracts and agro‐industry material) and of possible interest …

Two phenotypes exist in the human population with regard to expression of lactase in adults.
Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized …

Genetic disorders resulting from defects in the adult globin genes are among the most
common inherited diseases. Symptoms worsen from birth as fetal γ-globin expression is …

At high DNA concentration, as found in the nucleus, DNA-binding proteins search for
specific binding sites by hopping between separate DNA strands. Here, we use 15N z …

The developmental regulation of γ‐globin gene expression has shaped research efforts to
establish therapeutic modalities for individuals affected with sickle cell disease (SCD). Fetal …

During development and erythropoiesis, globin gene expression is finely modulated through
an important network of transcription factors and chromatin modifying activities. In this report …

More than 70% of eukaryotic proteins are composed of multiple domains. However, most
studies of the search for DNA focus on individual protein domains and do not consider …

The switch from fetal (G γ and A γ) to adult (β and δ) globin gene expression occurs at birth,
leading to the gradual replacement of HbF with HbA. Genetic regulation of this switch has …

The human embryonic, fetal and adult β-like globin genes provide a paradigm for tissue-and
developmental stage-specific gene regulation. The fetal γ-globin gene is expressed in fetal …