Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

DC Liemburg-Apers, PHGM Willems… - Archives of …, 2015 - Springer
Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …

[HTML][HTML] Glucose transporters in cardiac metabolism and hypertrophy

D Shao, R Tian - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

S Pich, D Bach, P Briones, M Liesa… - Human molecular …, 2005 - academic.oup.com
Abstract Mitofusin-2 (Mfn2) is a mitochondrial membrane protein that participates in
mitochondrial fusion in mammalian cells and mutations in the Mfn2 gene cause Charcot …

Will the original glucose transporter isoform please stand up!

A Carruthers, J DeZutter, A Ganguly… - American Journal of …, 2009 - journals.physiology.org
Monosaccharides enter cells by slow translipid bilayer diffusion by rapid, protein-mediated,
cation-dependent cotransport and by rapid, protein-mediated equilibrative transport. This …

The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated …

W Ma, W Lim, K Gee, S Aucoin, D Nandan… - Journal of Biological …, 2001 - ASBMB
Interleukin-10 (IL-10), a pleiotropic cytokine that inhibits inflammatory and cell-mediated
immune responses, is produced by a wide variety of cell types including T and B cells and …

Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle

A Zorzano, M Palacin, A Guma - Acta Physiologica …, 2005 - Wiley Online Library
Skeletal muscle is a major glucose‐utilizing tissue in the absorptive state and the major
glucose transporter expressed in muscle in adulthood is GLUT4. GLUT4 expression is …

Regulation of glucose transport by hypoxia

JZ Zhang, A Behrooz, F Ismail-Beigi - American Journal of Kidney Diseases, 1999 - Elsevier
Transport of glucose into most mammalian cells and tissues is rate-controlling for its
metabolism. Glucose transport is acutely stimulated by hypoxic conditions, and the response …

Control of mitochondrial biogenesis during myogenesis

CS Kraft, CMR LeMoine, CN Lyons… - … of Physiology-Cell …, 2006 - journals.physiology.org
We used expression and reporter gene analysis to understand how changes in transcription
factors impinge on mitochondrial gene expression during myogenesis of cultured murine …

A novel role of neuregulin in skeletal muscle: neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells

E Suárez, D Bach, J Cadefau, M Palacı́n… - Journal of biological …, 2001 - ASBMB
Neuregulins regulate the expression of acetylcholine receptor genes and induce
development of the neuromuscular junction in muscle. In studying whether neuregulins …

An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro

K Su, MD Roos, X Yang, I Han, AJ Paterson… - Journal of Biological …, 1999 - ASBMB
The transcription factor Sp1 is important for the expression of many cellular genes.
Previously, it was shown that reduced O-glycosylation of Sp1 is associated with increased …