Type 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic β-cells,
leading to the destruction of insulitis-related islet β-cells. Islet β-cell transplantation has been …

It is well recognized that chronic low-grade systemic inflammation and autoimmunity
contribute to the pathogenesis of metabolic syndrome, its associated diseases (eg type 2 …

Islet/β-cell transplantation offers great hope for patients with type 1 diabetes. We assessed
the mechanisms of how intrahepatic coinfusion of human α-1 antitrypsin (hAAT)-engineered …

Early apoptosis of grafted islets is one of the main factors affecting the efficacy of islet
transplantation. The combined transplantation of islet cells and bone marrow mesenchymal …

Simple Summary The overexpression of human alpha-1 antitrypsin (hAAT) in mesenchymal
stromal cells (MSCs) improved their intrinsic properties with enhanced protective effects in …

Chronic pancreatitis (CP) is a progressive inflammatory disorder that impairs endocrine and
exocrine function. Our previous work showed that mesenchymal stem/stromal cells (MSCs) …

Chronic pancreatitis (CP) is characterized by pancreatic inflammation, fibrosis, and
abdominal pain that is challenging to treat. Mesenchymal stromal cells (MSCs) …

According to the previous studies, chronic low-grade systemic inflammatory response has
been shown to be significantly associated with the pathological development of cardio …

Alpha-1 antitrypsin-overexpressing mesenchymal stromal/stem cells (AAT-MSCs) showed
improved innate properties with a faster proliferation rate when studied for their protective …

Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-
cells themselves. Restoration of regulated insulin production is a predominant goal of …