The gut virome: A new microbiome component in health and disease

Z Cao, N Sugimura, E Burgermeister, MP Ebert… - …, 2022 - thelancet.com
The human gastrointestinal tract harbours an abundance of viruses, collectively known as
the gut virome. The gut virome is highly heterogeneous across populations and is linked to …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

Expanding known viral diversity in the healthy infant gut

SA Shah, L Deng, J Thorsen, AG Pedersen… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

The gut virome is associated with stress-induced changes in behaviour and immune responses in mice

NL Ritz, LA Draper, TFS Bastiaanssen… - Nature …, 2024 - nature.com
The microbiota–gut–brain axis has been shown to play an important role in the stress
response, but previous work has focused primarily on the role of the bacteriome. The gut …

Rhizosphere phage communities drive soil suppressiveness to bacterial wilt disease

K Yang, X Wang, R Hou, C Lu, Z Fan, J Li, S Wang… - Microbiome, 2023 - Springer
Background Bacterial viruses, phages, play a key role in nutrient turnover and lysis of
bacteria in terrestrial ecosystems. While phages are abundant in soils, their effects on plant …

Extracellular vesicles from nanomedicine‐trained intestinal microbiota substitute for fecal microbiota transplant in treating ulcerative colitis

M Zu, G Liu, H Xu, Z Zhu, J Zhen, B Li, X Shi… - Advanced …, 2024 - Wiley Online Library
The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical
application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular …

Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review

Y Yang, H Du, G Zou, Z Song, Y Zhou, H Li… - Journal of Controlled …, 2023 - Elsevier
Intestinal flora regulation is an effective method to intervene and treat diseases associated
with microbiome imbalance. In addition to conventional probiotic supplement, phage …

Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity

M Zuppi, T Vatanen, BC Wilson, E Golovina, T Portlock… - Microbiome, 2024 - Springer
Background Fecal microbiota transplantation (FMT) is a therapeutic intervention used to
treat diseases associated with the gut microbiome. In the human gut microbiome, phages …

Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives

H Raeisi, M Noori, M Azimirad, SR Mohebbi… - Gut Pathogens, 2023 - Springer
Clostridioides difficile, which causes life-threatening diarrheal disease, is considered an
urgent threat to healthcare setting worldwide. The current standards of care solely rely on …

[HTML][HTML] Early gut microbiota intervention in premature infants: Application perspectives

Q Xiang, X Yan, W Shi, H Li, K Zhou - Journal of Advanced Research, 2023 - Elsevier
Background Preterm birth is the leading cause of death in children under the age of five.
One of the major factors contributing to the high risk of diseases and deaths in premature …