Lipid droplets and lipid mediators in viral infection and immunity

EA Monson, AM Trenerry, JL Laws… - FEMS microbiology …, 2021 - academic.oup.com
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Viperin reveals its true function

EE Rivera-Serrano, AS Gizzi, JJ Arnold… - Annual review of …, 2020 - annualreviews.org
Most cells respond to viral infections by activating innate immune pathways that lead to the
induction of antiviral restriction factors. One such factor, viperin, was discovered almost two …

Viperin restricts Zika virus and tick-borne encephalitis virus replication by targeting NS3 for proteasomal degradation

C Panayiotou, R Lindqvist, C Kurhade… - Journal of …, 2018 - Am Soc Microbiol
Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with
millions of human infections annually. Their pathogenesis ranges from mild illness to severe …

Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity

S Ghosh, ENG Marsh - Journal of Biological Chemistry, 2020 - ASBMB
Viperin plays an important and multifaceted role in the innate immune response to viral
infection. Viperin is also notable as one of very few radical SAM–dependent enzymes …

Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation

FS Pereira-Dutra, L Teixeira… - Journal of leukocyte …, 2019 - academic.oup.com
Increased accumulation of cytoplasmic lipid droplets (LDs) in host nonadipose cells is
commonly observed in response to numerous infectious diseases, including bacterial …

Hemorrhagic fever-causing arenaviruses: lethal pathogens and potent immune suppressors

ME Brisse, H Ly - Frontiers in immunology, 2019 - frontiersin.org
Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis

AB Dumbrepatil, S Ghosh, KA Zegalia, PA Malec… - Journal of Biological …, 2019 - ASBMB
Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (viperin) is a
radical SAM enzyme that plays a multifaceted role in the cellular antiviral response. Viperin …

Cell lipid biology in infections: an overview

LG Prado, NOS Camara, AS Barbosa - Frontiers in Cellular and …, 2023 - frontiersin.org
Lipids are a big family of molecules with a vast number of functions in the cell membranes,
within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage …

Lipid droplets diversity and functions in inflammation and immune response

FS Pereira-Dutra, PT Bozza - Expert Review of Proteomics, 2021 - Taylor & Francis
ABSTRACT Introduction Lipid droplets (LDs) are dynamic and evolutionary conserved lipid-
enriched organelles composed of a core of neutral lipids surrounded by a monolayer of …

The virus–host interplay in Junín mammarenavirus infection

GL Gallo, N López, ME Loureiro - Viruses, 2022 - mdpi.com
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of
Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas …