As epigenetic therapies continue to gain ground as potential treatment strategies for cancer
and other diseases, compounds that target histone lysine methylation and the enzyme …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Liver cancer is among the leading causes of cancer-related death worldwide and China
accounts for nearly half of the global burden of liver cancer. Effective interventions such as …

In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

Endometrial cancer (EC) is a common malignancy of the female reproductive system, with
an escalating incidence. Recurrent/metastatic EC presents a poor prognosis. The interaction …

Immune checkpoint blockade therapy has revolutionized the field of cancer treatment,
leading to durable responses in patients with advanced and metastatic cancers where …

DNA methyltransferase inhibitor (DNMTi) efficacy in solid tumors is limited. Colon cancer
cells exposed to DNMTi accumulate lysine-27 trimethylation on histone H3 (H3K27me3). We …

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death. The
accumulation of genetic and epigenetic changes is closely related to the occurrence and …

Many natural products can exert anticancer or chemopreventive activity by interfering with
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …

Pancreatic ductal adenocarcinoma (PDAC) is a highly life-threatening tumour with a low
early-detection rate, rapid progression and a tendency to develop resistance to …