Thromboxane A2 receptors (TPs) are widely distributed among different organ systems and
have been localized on both cell membranes and intracellular structures. Following the …

Although hyperuricemia has long been associated with renal disease, uric acid has not
been considered as a true mediator of progression of renal disease. The observation that …

Hyperuricemia is associated with renal disease, but it is usually considered a marker of
renal dysfunction rather than a risk factor for progression. Recent studies have reported that …

Vascular inflammation was examined as a potential mechanism of aldosterone-mediated
myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or …

We studied the role of aldosterone (aldo) in myocardial injury in a model of angiotensin
(Ang) II-hypertension. Wistar rats were given 1% NaCl (salt) to drink and randomized into …

Although accumulating lines of evidence indicate the proangiogenic role of angiotensin II
(Ang II), little is known about the molecular mechanisms associated with such an effect. This …

Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-
oxygenases has been involved in the alterations in vascular function, structure and …

Angiotensin II (Ang II) type 1 receptor (AT1) antagonists such as losartan (LOS) are widely
used for the treatment of hypertension and elicit antiinflammatory and antiaggregatory in …

Objective—Inflammation plays an integral role in the development of abdominal aortic
aneurysms (AAAs), and the expression of cyclooxygenase (COX)-2 is increased in …

Objective: Abnormalities in vascular constriction and dilatation are associated with early
diabetes and contribute to diabetic vascular complications. However, mechanisms …