Transforming growth factor-β (TGFβ) signalling, particularly signalling from the bone
morphogenetic protein (BMP) members of this protein family, is crucial for the development …

Bone morphogenetic proteins (BMPs) are multifunctional growth factors belonging to the
transforming growth factor beta (TGFβ) multigene family. Current evidence indicates that …

Expression of the Wnt signaling inhibitor, DKK1 by multiple myeloma cells is correlated with
lytic bone disease in multiple myeloma. However, the mechanism (s) by which DKK1 …

TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions
ranging from innate and adaptive immune system activation to vascular development and …

Background The advanced phases of chronic myeloid leukemia (CML) are known to be
more resistant to therapy. This resistance has been associated with the overexpression of …

During the onset and progression of atherosclerosis, the vascular smooth muscle cell
(VSMC) phenotype changes from differentiated to dedifferentiated, and in some cases, this …

Background Bone morphogenetic protein 4 (BMP4) plays an important role in cancer
pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line …

Bone morphogenetic protein (BMP) signaling plays an essential role in early tooth
development, evidenced by disruption of BMP signaling leading to an early arrested tooth …

Abstract Background One of Darwin's chosen examples for his idea of sexual selection
through female choice was the" sword", a colourful extension of the caudal fin of male …

Polycomb proteins form multiprotein complexes that repress target genes by chromatin
remodeling. In this work, we report that the SUZ12 polycomb gene is over‐expressed in …