The proteins of keratoconus: a literature review exploring their contribution to the pathophysiology of the disease

E Loukovitis, N Kozeis, Z Gatzioufas, A Kozei… - Advances in …, 2019 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous multifactorial
degenerative disorder characterized by corneal ectasia and thinning. Its incidence is …

Keratoconus

RB Singh, S Koh, N Sharma, FA Woreta… - Nature Reviews …, 2024 - nature.com
Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …

Systematically Displaying the Pathogenesis of Keratoconus via Multi-Level Related Gene Enrichment-Based Review

XD Hao, H Gao, WH Xu, C Shan, Y Liu, ZX Zhou… - Frontiers in …, 2022 - frontiersin.org
Keratoconus (KC) is an etiologically heterogeneous corneal ectatic disorder. To
systematically display the pathogenesis of keratoconus (KC), this study reviewed all the …

Corneal allografts: factors for and against acceptance

J Sakowska, P Glasner, M Zieliński… - Journal of …, 2021 - Wiley Online Library
Cornea is one of the most commonly transplanted tissues worldwide. However, it is usually
omitted in the field of transplantology. Transplantation of the cornea is performed to treat …

CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues

RL Gendron, H Paradis, R Ahmad, K Kao… - Frontiers in …, 2020 - frontiersin.org
Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner “fish, is utilized to biocontrol
salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish …

[HTML][HTML] Integrative transcriptomics analysis and experimental validation reveal immunomodulatory patterns in keratoconus

X Chen, C Liu, Z Cui, Y Huang, Q Luo, S Chen… - Experimental Eye …, 2023 - Elsevier
Keratoconus is a progressive disorder of the cornea and is typically considered a
noninflammatory disease. However, increasing evidence indicates that immune disorders …

Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level

F Meng, S Ren - International Ophthalmology, 2024 - Springer
Objective Keratoconus (KC) is a condition characterized by progressive corneal steepening
and thinning. However, its pathophysiological mechanism remains vague. We mainly …

Polymorphisms of the apoptosis-related FAS and FAS ligand genes in keratoconus and Fuchs endothelial corneal dystrophy

E Synowiec, KA Wojcik, J Izdebska… - The Tohoku Journal of …, 2014 - jstage.jst.go.jp
Keratoconus (KC) is a non-inflammatory eye disease characterized by progressive corneal
thinning and asymmetrical conical protrusion of the cornea. Fuchs endothelial corneal …

Inflammation in keratoconus

R Shetty, P Khamar, G Kundu, A Ghosh, S Sethu - Keratoconus, 2023 - Elsevier
Keratoconus (KC) is a corneal ectatic condition characterized by focal structural changes
resulting in biomechanical weakening of the cornea leading to irregular astigmatism …

Neprilysin inhibition promotes corneal wound healing

RM Genova, KJ Meyer, MG Anderson, MM Harper… - Scientific reports, 2018 - nature.com
Neprilysin (NEP), an ectoenzyme that modulates inflammation by degrading neuropeptides,
was recently identified in the human corneal epithelium. The cornea expresses many NEP …