Natural products from plants targeting key enzymes for the future development of antidiabetic agents

R Mata, L Flores-Bocanegra… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2000 to January 2023 Diabetes is a metabolic disease of serious concern
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …

Bioactive peptides: An understanding from current screening methodology

NTP Nong, JL Hsu - Processes, 2022 - mdpi.com
Bioactive peptides with high potency against numerous human disorders have been
regarded as a promising therapy in disease control. These peptides could be released from …

Screening of natural inhibitors against peptidyl arginine deiminase 4 from herbal extracts by a high-performance liquid chromatography ultraviolet-visible based …

J Zhao, Y Li, C Gao, Z Zhao, S Zhang, J Dong… - … of Chromatography A, 2024 - Elsevier
Abstract Peptidyl arginine deiminase 4 (PAD4) is an important biocatalytic enzymes involved
in the conversion of protein arginine to citrulline, its dysregulation has a great impact on …

A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants

LH Gu, LP Liao, HJ Hu, SWA Bligh, CH Wang… - … of Chromatography A, 2015 - Elsevier
A thin-layer chromatography (TLC)-bioautographic method was developed with the aim to
detect dipeptidyl peptidase IV (DPP IV) inhibitors from plant extracts. The basic principle of …

Visualizing Dipeptidyl Peptidase-IV with an Advanced Non-π-Conjugated Fluorescent Probe for Early Thyroid Disease Diagnosis

J Li, M Ma, J Li, L Xu, D Song, P Ma, Q Fei - Analytical Chemistry, 2023 - ACS Publications
Early detection and effective treatment of thyroid cancer are vital due to the aggressiveness
and high mortality rate of the cancer. Nevertheless, the exploration of dipeptidyl peptidase-IV …

Macrocarpal C isolated from Eucalyptus globulus inhibits dipeptidyl peptidase 4 in an aggregated form

E Kato, K Kawakami, J Kawabata - Journal of enzyme inhibition …, 2018 - Taylor & Francis
Abstract Dipeptidyl peptidase 4 (DPP-4) inhibitors are used for the treatment of type-2
diabetes mellitus. Various synthetic inhibitors have been developed to date, and plants …

Inhibitory potency of Withania somnifera extracts against DPP-4: an in vitro evaluation

PK Kempegowda, F Zameer, CK Narasimashetty… - African Journal of …, 2018 - ajol.info
Background: Pharmacologic treatments for type 2 diabetes are based upon increasing
insulin availability and improving sensitivity to insulin. Nowadays, glucagon like peptide-1 …

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

S Rhee, YJ Choi, SH Lee, J Oh, SJ Kim… - Drug Design …, 2016 - Taylor & Francis
Evogliptin is a newly developed dipeptidyl peptidase-4 (DPP-4) inhibitor, which is expected
to be combined with metformin for treating type 2 diabetes mellitus. We investigated the …

A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly

Y Zhao, J Zou, Y Song, J Peng, Y Wang… - Chemical …, 2020 - pubs.rsc.org
This article presents a new label-free fluorescence assay based on supramolecular self-
assembly of cucurbit [7] uril and specific peptide Gly-Pro-Phe-Gly for monitoring DPP4 …

A new method for screening aldose reductase inhibitors using ultrahigh performance liquid chromatography-tandem mass spectrometry

G Hou, R Zhang, Z Pi, F Song, Z Liu, S Liu - Analytical Methods, 2014 - pubs.rsc.org
In this study, an ultrahigh performance liquid chromatography and tandem mass
spectrometry (UPLC-MS/MS) method was developed for the detection of aldose reductase …