G protein–coupled receptors engage both G proteins and β-arrestins, and their coupling can
be biased by ligands and mutations. Here, to resolve structural elements and mechanisms …

Olfactory receptors (ORs) form the most important chemosensory receptor family responsible
for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the …

Odorant receptors (ORs) belong to a large family of G protein-coupled receptors (GPCRs)
that are highly expressed by olfactory sensory neurons of the nose. Accumulating evidence …

A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …

Conserved protein-coding sequences are critical for maintaining protein function across
species. Odorant receptors (ORs), a large poorly understood multigene family responsible …

Humans have approximately 400 different olfactory receptors (hORs) and recognize
odorants through the repertoire of hOR responses. Although the cell surface expression of …

Mammalian odorant receptors (ORs) are crucial for detecting a broad spectrum of odorants,
yet their functional expression poses a significant challenge, often requiring Receptor …

Nootkatone is one of the most valuable citrus flavors. Originally isolated from the heartwood
of the Nootka cypress (Callitropsis nootkatensis), it was probably the identification of …

抄録 嗅細胞に発現する嗅覚受容体 (OR) は匂い物質の受容に重要な役割を担っている.
匂い受容のメカニズムをより深く理解するためには, OR のリガンドの同定, すなわち 「OR …