The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

It is well established that tissue repair depends on stem cells and that chronic wounds
predispose to tumour formation. However, the association between stem cells, wound …

Constitutively activated NF-κB occurs in many inflammatory and tumor tissues. Does it
interfere with anti-inflammatory or anti-tumor signaling pathway? Here, we report that NF-κB …

Health reflects the ability of an organism to adapt to stress. Stresses—metabolic, proteotoxic,
mitotic, oxidative and DNA-damage stresses—not only contribute to the etiology of cancer …

Human exposures to environmental toxicants have been associated with development of a
number of diseases. Animal experiments have identified a number of cytoprotective …

The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for
the development of more efficacious strategies targeting diabetic wound healing. In the …

Although tremendous progress has been achieved in understanding the molecular basis of
tissue repair and regeneration in diverse model organisms, the tendency of mammals for …

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and
provokes stellate cell activation, with secretion of scar matrix. Conditions that augment …

Modulation of the metabolism and disposition of carcinogens through induction of
cytoprotective enzymes is one of several promising strategies to prevent cancer …