Advances in the diagnosis of tuberculosis

C Lange, T Mori - Respirology, 2010 - Wiley Online Library
Tuberculosis ranges among the leading causes of morbidity and mortality worldwide. A
diagnostic approach to a patient with possible tuberculosis includes a detailed medical …

Local immune responses in human tuberculosis: learning from the site of infection

S Brighenti, J Andersson - Journal of Infectious Diseases, 2012 - academic.oup.com
Host–pathogen interactions in tuberculosis should be studied at the disease site because
Mycobacterium tuberculosis is predominately contained in local tissue lesions. Although M …

Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study

C Jafari, S Thijsen, G Sotgiu, D Goletti… - American journal of …, 2009 - atsjournals.org
Rationale: The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast
bacilli (AFB) cannot be detected in sputum smears. Objectives: Following a proof of principle …

Adjunctive tests for diagnosis of tuberculosis: serology, ELISPOT for site-specific lymphocytes, urinary lipoarabinomannan, string test, and fine needle aspiration

JM Achkar, SD Lawn, MYS Moosa… - Journal of Infectious …, 2011 - academic.oup.com
The diagnostic gold standard for active tuberculosis (TB) is the detection of Mycobacterium
tuberculosis (MTB) by culture or molecular methods. However, despite its limited sensitivity …

Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery

S Kunnath-Velayudhan… - Clinical microbiology …, 2011 - Am Soc Microbiol
Infection with Mycobacterium tuberculosis causes a variety of clinical conditions ranging
from life-long asymptomatic infection to overt disease with increasingly severe tissue …

Complexity and controversies over the cytokine profiles of T helper cell subpopulations in tuberculosis

MV da Silva, MGS Tiburcio, JR Machado… - Journal of …, 2015 - Wiley Online Library
Tuberculosis (TB) is a contagious infectious disease caused by the TB‐causing bacillus
Mycobacterium tuberculosis and is considered a public health problem with enormous …

Application of Venn's diagram in the diagnosis of pleural tuberculosis using IFN-γ, IP-10 and adenosine deaminase

AP Santos, RS Corrêa, M Ribeiro-Alves… - PloS one, 2018 - journals.plos.org
Background Pleural tuberculosis (PlTB) is the most common extrapulmonary manifestation
of this infectious disease which still presents high mortality rates worldwide. Conventional …

Interferon-gamma release assay performance of pleural fluid and peripheral blood in pleural tuberculosis

F Liu, M Gao, X Zhang, F Du, H Jia, X Yang, Z Wang… - PLoS …, 2013 - journals.plos.org
Background The diagnosis of pleural tuberculosis (TB) remains to be difficult. Interferon-
gamma release assay (IGRA) is a promising method for diagnosing TB in low TB burden …

Gamma interferon immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy

M Liao, Q Yang, J Zhang, M Zhang… - Clinical and Vaccine …, 2014 - Am Soc Microbiol
Diagnosis of tuberculous pleurisy remains a challenge in the clinic. In this study, we
evaluated the usefulness of a previously developed Mycobacterium tuberculosis antigen …

Regions of differences encoded antigens as targets for immunodiagnosis of tuberculosis in humans

O Parkash, BP Singh, M Pai - Scandinavian journal of …, 2009 - Wiley Online Library
Tuberculosis is one of the major global health problems causing nearly 2 million deaths
every year. It continues to be a leading cause of morbidity and mortality in developing …