Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Conspectus The field of gene therapy, which aims to treat patients by modulating gene
expression, has come to fruition and has landed several landmark FDA approvals. Most …

Trehalose is a naturally occurring, nonreducing disaccharide that is widely used in the
biopharmaceutical, food, and cosmetic industries due to its stabilizing and cryoprotective …

Polycations are useful delivery vehicles for nucleic acids and proteins. Physicochemical
properties, safety, and cost are important design parameters for polycation-enabled …

Epoxy resins are ubiquitous in high-performance composite applications because of their
excellent mechanical strength, thermal and chemical resistance, strong adhesion, and low …

The chitosan oligosaccharide-based disulfide-containing polyethylenimine derivative PEG-
ss-COS-ss-PEI was synthesized and evaluated as a nonviral gene delivery carrier. The …

The liver is an ideal target for nucleic acid therapeutic applications (ie, siRNA, gene therapy,
and genome editing) due to its ability to secrete proteins into the blood. In this work, we …

The development and thorough characterization of nonviral delivery agents for nucleic acid
and genome editing therapies are of high interest to the field of nanomedicine. Indeed, this …

A series of nine poly (2-deoxy-2-methacrylamido glucopyranose)-b-poly (methacrylate
amine) diblock copolycations has been synthesized as new colloidally stable polynucleotide …

Polymeric and hybrid nanoparticles have received increased scientific interest in terms of
basic research as well as commercial applications, promising a variety of uses for …