Every sixth person in the world dies due to cancer, making it the second leading severe
cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 …

Cancer is a complex, multiscale process in which genetic mutations occurring at a
subcellular level manifest themselves as functional changes at the cellular and tissue scale …

Effective translational methodologies for knowledge representation are needed in order to
make strides against the constellation of diseases that affect the world today. These …

Abstract Systems Biology has taken advantage of computational tools and high-throughput
experimental data to model several biological processes. These include signaling, gene …

Hierarchical processes spanning several orders of magnitude of both space and time
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …

Emergent behaviors of multi-cellular biological systems (MCBS) result from the behaviors of
each individual cells and their interactions with other cells and with the environment …

We provide a rationale for and describe examples of synthetic modeling and simulation
(M&S) of biological systems. We explain how synthetic methods are distinct from familiar …

Background Simulation of sophisticated biological models requires considerable
computational power. These models typically integrate together numerous biological …

Multicellular aggregates are known to exhibit liquid-like properties. The fusion process of
two cell aggregates is commonly studied as the coalescence of two viscous drops. However …

We provide an overview of computational systems biology approaches as applied to the
study of chemical-and drug-induced toxicity. The concept of “toxicity pathways” is described …