Ecto-ATPases are ubiquitous in eukaryotic cells. They hydrolyze extracellular nucleoside tri-
and/or diphosphates, and, when isolated, they exhibit E-type ATPase activity,(that is, the …

Detached synapses (synaptosomes), first isolated by the author in 1958 and identified as
such in 1960, are sealed presynaptic nerve terminals often with a portion of the target cell …

Hydrogen sulfide (H2S) is a synaptic modulator as well as a neuroprotectant. Currently,
pyridoxal-5′-phosphate (PLP)-dependent cystathionine β-synthase (CBS) is thought to be …

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene
as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE …

The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-
resistant forms (PrPSc) believed to cause scrapie, bovine spongiform encephalopathy (BSE) …

Homogenization of fresh brain tissue in isotonic medium shears plasma membranes
causing nerve terminals to become separated from their axons and postsynaptic …

Two procedures are described for isolating free (nonsynaptosomal) mitochondria from rat
brain. Both procedures employ a discontinuous Percoll gradient and yield well coupled …

A new rapid method for fractionation of crude synaptosomes (postmitochondrial pellet, P2)
on a discontinuous 4-step Percoll gradient is described. The homogeneity and integrity of …

A method for preparation of synaptosomes from rat cerebral cortex, on a discontiinuous
Percoll gradient, was previously developed for use with a P 2 pellet (Brain Research, 372 …

Free radicals are known to cause secondary neuronal damage in cerebral
ischemia/reperfusion (I/R). We investigated here the neuroprotective effect of resveratrol, a …