The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

[HTML][HTML] Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?

C Hohenfeld, CJ Werner, K Reetz - NeuroImage: Clinical, 2018 - Elsevier
Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

[HTML][HTML] Genuine high-order interactions in brain networks and neurodegeneration

R Herzog, FE Rosas, R Whelan, S Fittipaldi… - Neurobiology of …, 2022 - Elsevier
Brain functional networks have been traditionally studied considering only interactions
between pairs of regions, neglecting the richer information encoded in higher orders of …

Functional brain networks in the evaluation of patients with neurodegenerative disorders

M Perovnik, T Rus, KA Schindlbeck… - Nature Reviews …, 2023 - nature.com
Network analytical tools are increasingly being applied to brain imaging maps of resting
metabolic activity (PET) or blood oxygenation-dependent signals (functional MRI) to …

Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation

V Bachtiar, J Near, H Johansen-Berg, CJ Stagg - elife, 2015 - elifesciences.org
We previously demonstrated that network level functional connectivity in the human brain
could be related to levels of inhibition in a major network node at baseline. In this study, we …

Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms

KS Hemington, Q Wu, A Kucyi, RD Inman… - Brain Structure and …, 2016 - Springer
Cortical functioning within the default mode network (DMN) and salience network (SN) is
altered in chronic pain patients. The mechanisms underlying these alterations are unknown …

Gray matter asymmetries in aging and neurodegeneration: A review and meta‐analysis

L Minkova, A Habich, J Peter, CP Kaller… - Human brain …, 2017 - Wiley Online Library
Inter‐hemispheric asymmetries are a common phenomenon of the human brain. Some
evidence suggests that neurodegeneration related to aging and disease may preferentially …

Network imaging biomarkers: insights and clinical applications in Parkinson's disease

KA Schindlbeck, D Eidelberg - The Lancet Neurology, 2018 - thelancet.com
Parkinson's disease presents several practical challenges: it can be difficult to distinguish
from atypical parkinsonian syndromes, clinical ratings can be insensitive as markers of …

Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network

EA Oyarzabal, LM Hsu, M Das, THH Chao, J Zhou… - Science …, 2022 - science.org
The default mode network (DMN) of the brain is functionally associated with a wide range of
behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron …