Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

The T-cell leukaemia/lymphoma 1 (TCL1)-family oncoproteins augment AKT signal
transduction and enhance cell proliferation and survival. Chromosome rearrangements …

POU transcription factor Pou5f1 (Oct3/4) is required to maintain ES cells in an
undifferentiated state. Here we show that global expression profiling of Oct3/4-manipulated …

B cell chronic lymphocytic leukemia (B-CLL) is a clonal overgrowth of CD5+ B lymphocytes.
In this disease, the B cell antigen receptor (BCR) is intimately linked to disease severity …

Chromosomal rearrangements observed in T-cell prolymphocytic leukemia involve the
translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, deregulating …

Simple Summary T-cell leukemia/lymphoma 1A (TCL1A) is a proto-oncogene that is mainly
expressed in embryonic and fetal tissues, as well as in some lymphatic cells. It is frequently …

Overexpression of the TCL1 oncogene has been shown to play a causative role in T cell
leukemias of humans and mice. The characterization of Tcl1-deficient mice in these studies …

Stored maternal factors in oocytes regulate oocyte differentiation into embryos during early
embryonic development. Before zygotic gene activation (ZGA), these early embryos are …

The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal
translocations and inversions at 14q31. 2, and its rearrangement in T cells causes T-cell …

Background Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian
folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify …