[HTML][HTML] NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer's Disease

BS Sivamaruthi, N Raghani, M Chorawala… - Biomedicines, 2023 - mdpi.com
The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the
pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer's …

[HTML][HTML] Computer-aided drug design towards new psychotropic and neurological drugs

G Dorahy, JZ Chen, T Balle - Molecules, 2023 - mdpi.com
Central nervous system (CNS) disorders are a therapeutic area in drug discovery where
demand for new treatments greatly exceeds approved treatment options. This is complicated …

Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders.

A Kumar, F Kim, DK Song, JJ Choung - Aging & Disease, 2023 - search.ebscohost.com
The prevalence of neurocognitive disorders (NCD) increases every year as the population
continues to age, leading to significant global health concerns. Overcoming this challenge …

Effect of PDE 5 Inhibitor-Avanafil on Renal Ischemia/Reperfusion Injury in Rats.

TN YÜKSEL, Z HALICI, C KAYA… - Namık Kemal Tıp …, 2023 - search.ebscohost.com
Aim: Renal ischemia-reperfusion injury (RI/RI) damages many organs, especially the kidney.
Phosphodiesterase (PDE) 5 inhibitors has antioxidant and anti-inflammatory effects. Avanafil …

[HTML][HTML] Sıçanlarda Renal İskemi/Reperfüzyon Hasarı Üzerine PDE 5 İnhibitörü-Avanafilin Etkisi

TN YÜKSEL, Z HALICI, K Cihangir, A BOZKURT… - 2023 - namikkemalmedj.com
Amaç: Renal iskemi-reperfüzyon hasarı (RI/RI) başta böbrek olmak üzere birçok organa
zarar verir. Fosfodiesteraz (PDE) 5 inhibitörleri, antioksidan ve anti-enflamatuvar etkilere …