Mitochondrial signal transduction

M Picard, OS Shirihai - Cell Metabolism, 2022 - cell.com
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Function and regulation of the divisome for mitochondrial fission

F Kraus, K Roy, TJ Pucadyil, MT Ryan - Nature, 2021 - nature.com
Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

The multiple links between actin and mitochondria

TS Fung, R Chakrabarti, HN Higgs - Nature Reviews Molecular Cell …, 2023 - nature.com
Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome

MJ Barrera, S Aguilera, I Castro, P Carvajal, D Jara… - Autoimmunity …, 2021 - Elsevier
Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

The muscle-brain axis and neurodegenerative diseases: the key role of mitochondria in exercise-induced neuroprotection

J Burtscher, GP Millet, N Place, B Kayser… - International Journal of …, 2021 - mdpi.com
Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease

SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …

Mitochondria: in the cross fire of SARS-CoV-2 and immunity

J Burtscher, G Cappellano, A Omori, T Koshiba… - IScience, 2020 - cell.com
The pathophysiology, immune reaction, and differential vulnerability of different population
groups and viral host immune system evasion strategies of severe acute respiratory …

[HTML][HTML] The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic

J Burtscher, M Burtscher, GP Millet - Redox biology, 2021 - Elsevier
Mitochondria are central regulators of cellular metabolism, most known for their role in
energy production. They can be “enhanced” by physical activity (including exercise), which …

Mitochondria in disease: changes in shapes and dynamics

BC Jenkins, K Neikirk, P Katti, SM Claypool… - Trends in biochemical …, 2024 - cell.com
Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …