Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act
as ligand-activated transcription factors. PPAR agonists have well-documented anti …

Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

Cannabinoids act at two classical cannabinoid receptors (CB1 and CB2), a 7TM orphan
receptor and the transmitter‐gated channel transient receptor potential vanilloid type‐1 …

Cannabinoids act via cell surface G protein-coupled receptors (CB1 and CB2) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging
as an important target in the brain for the treatment or prevention of cognitive disorders. The …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …