Ancient DNA analysis
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
A large genome center's improvements to the Illumina sequencing system
MA Quail, I Kozarewa, F Smith, A Scally, PJ Stephens… - Nature …, 2008 - nature.com
Abstract The Wellcome Trust Sanger Institute is one of the world's largest genome centers,
and a substantial amount of our sequencing is performed with'next-generation'massively …
and a substantial amount of our sequencing is performed with'next-generation'massively …
Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments
INTRODUCTION The study of hominin history has progressed through both archaeological
and genetic insights. Although DNA sequencing from hominin skeletal remains allows the …
and genetic insights. Although DNA sequencing from hominin skeletal remains allows the …
A high-coverage genome sequence from an archaic Denisovan individual
We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
A draft sequence of the Neandertal genome
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …
Europe and western Asia before disappearing 30,000 years ago. We present a draft …
Illumina sequencing library preparation for highly multiplexed target capture and sequencing
The large amount of DNA sequence data generated by high-throughput sequencing
technologies often allows multiple samples to be sequenced in parallel on a single …
technologies often allows multiple samples to be sequenced in parallel on a single …
Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs
O Thalmann, B Shapiro, P Cui, VJ Schuenemann… - Science, 2013 - science.org
The geographic and temporal origins of the domestic dog remain controversial, as genetic
data suggest a domestication process in East Asia beginning 15,000 years ago, whereas …
data suggest a domestication process in East Asia beginning 15,000 years ago, whereas …
[HTML][HTML] Genomic analyses of hair from Ludwig van Beethoven
Summary Ludwig van Beethoven (1770–1827) remains among the most influential and
popular classical music composers. Health problems significantly impacted his career as a …
popular classical music composers. Health problems significantly impacted his career as a …
Single-stranded DNA library preparation from highly degraded DNA using T4 DNA ligase
MT Gansauge, T Gerber, I Glocke… - Nucleic acids …, 2017 - academic.oup.com
DNA library preparation for high-throughput sequencing of genomic DNA usually involves
ligation of adapters to double-stranded DNA fragments. However, for highly degraded DNA …
ligation of adapters to double-stranded DNA fragments. However, for highly degraded DNA …
Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting
M Ehrich, C Deciu, T Zwiefelhofer, JA Tynan… - American journal of …, 2011 - Elsevier
OBJECTIVE: We sought to evaluate a multiplexed massively parallel shotgun sequencing
assay for noninvasive trisomy 21 detection using circulating cell-free fetal DNA. STUDY …
assay for noninvasive trisomy 21 detection using circulating cell-free fetal DNA. STUDY …