COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

[HTML][HTML] The effect of convalescent plasma therapy on mortality among patients with COVID-19: systematic review and meta-analysis

SA Klassen, JW Senefeld, PW Johnson, RE Carter… - Mayo Clinic …, 2021 - Elsevier
To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated
patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose …

Efficacy and safety of COVID-19 convalescent plasma in hospitalized patients: a randomized clinical trial

MB Ortigoza, H Yoon, KS Goldfeld… - JAMA internal …, 2022 - jamanetwork.com
Importance There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in
patients hospitalized with COVID-19. Objective To determine the safety and efficacy of CCP …

The principles of antibody therapy for infectious diseases with relevance for COVID-19

A Casadevall, L Pirofski, MJ Joyner - MBio, 2021 - Am Soc Microbiol
Antibody therapies such as convalescent plasma and monoclonal antibodies have emerged
as major potential therapeutics for coronavirus disease 2019 (COVID-19). Immunoglobulins …

[HTML][HTML] Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19

SAA Egloff, A Junglen, JSA Restivo… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Evidence supporting convalescent plasma (CP), one of the first
investigational treatments for coronavirus disease 2019 (COVID-19), has been inconclusive …

[HTML][HTML] Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality

A Casadevall, Q Dragotakes, PW Johnson… - Elife, 2021 - elifesciences.org
Background: The US Food and Drug Administration authorized COVID-19 convalescent
plasma (CCP) therapy for hospitalized COVID-19 patients via the Expanded Access …

[HTML][HTML] Convalescent plasma therapy for COVID-19: a graphical mosaic of the worldwide evidence

SA Klassen, JW Senefeld, KA Senese… - Frontiers in …, 2021 - frontiersin.org
Convalescent plasma has been used worldwide to treat patients hospitalized with
coronavirus disease 2019 (COVID-19) and prevent disease progression. Despite global …

[HTML][HTML] Rates among hospitalized patients with COVID-19 treated with convalescent plasma: a systematic review and meta-analysis

JW Senefeld, EK Gorman, PW Johnson, ME Moir… - … : Innovations, Quality & …, 2023 - Elsevier
Objective To examine the association of COVID-19 convalescent plasma transfusion with
mortality and the differences between subgroups in hospitalized patients with COVID-19 …

[HTML][HTML] Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors

KL Kunze, PW Johnson, N van Helmond… - Nature …, 2021 - nature.com
Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have
harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

Y Ray, SR Paul, P Bandopadhyay, R D'Rozario… - Nature …, 2022 - nature.com
A single center open label phase 2 randomised control trial (Clinical Trial Registry of India
No. CTRI/2020/05/025209) was done to assess clinical and immunological benefits of …