Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

Extracellular vesicles in metabolic disease

N Akbar, V Azzimato, RP Choudhury, M Aouadi - Diabetologia, 2019 - Springer
Extracellular vesicles (EVs) are submicron-sized lipid envelopes that are produced and
released from a parent cell and can be taken up by a recipient cell. EVs are capable of …

Human neural stem cell extracellular vesicles improve tissue and functional recovery in the murine thromboembolic stroke model

RL Webb, EE Kaiser, SL Scoville, TA Thompson… - Translational stroke …, 2018 - Springer
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be
attributed in part to limited and isolated testing often solely in “young” rodent models and …

Isolation and analysis methods of extracellular vesicles (EVs)

Z Zhao, H Wijerathne, AK Godwin… - … vesicles and circulating …, 2020 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) have been recognized as an evolving biomarker within the
liquid biopsy family. While carrying both host cell proteins and different types of RNAs, EVs …

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology

AG Yates, RC Pink, U Erdbrügger… - Journal of …, 2022 - Wiley Online Library
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

Exosomes in inflammation and inflammatory disease

BD Chan, WY Wong, MML Lee, WCS Cho, BK Yee… - …, 2019 - Wiley Online Library
Exosomes are a subset of extracellular vesicles released by all cell types and involved in
local and systemic intercellular communication. In the past decade, research into exosomes …

Functional two-way crosstalk between brain and lung: the brain–lung axis

C Li, W Chen, F Lin, W Li, P Wang, G Liao… - Cellular and Molecular …, 2023 - Springer
The brain has many connections with various organs. Recent advances have demonstrated
the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the …

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells

L Yang, D Tucker, Y Dong, C Wu, Y Lu, Y Li… - Experimental …, 2018 - Elsevier
Recent work has indicated that photobiomodulation (PBM) may beneficially alter the
pathological status of several neurological disorders, although the mechanism currently …

Extracellular vesicles of Alzheimer's disease patients as a biomarker for disease progression

A Aharon, P Spector, RS Ahmad, N Horrany… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative brain pathology and the most
common form of dementia. Evidence suggests that extracellular vesicles (EVs) containing …

The evolving role of neuro‐immune interaction in brain repair after cerebral ischemic stroke

X Wang, W Xuan, ZY Zhu, Y Li, H Zhu… - CNS neuroscience & …, 2018 - Wiley Online Library
Stroke is the world's leading cause of disability with limited brain repair treatments which
effectively improve long‐term neurological deficits. The neuroinflammatory responses …