New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Application of the CRISPR/Cas9 system to drug resistance in breast cancer

Y Chen, Y Zhang - Advanced Science, 2018 - Wiley Online Library
Clinical evidence indicates that drug resistance is a great obstacle in breast cancer therapy.
It renders the disease uncontrollable and causes high mortality. Multiple mechanisms …

lncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway

Y Li, C Li, D Li, L Yang, J Jin, B Zhang - OncoTargets and therapy, 2019 - Taylor & Francis
Purpose The chemoresistance of colon cancer to oxaliplatin (L-OHP) indicates poor
prognosis. Long non-coding RNA (lncRNA) KCNQ1OT1 (KCNQ1 opposite strand/antisense …

Identification of potential crucial genes and key pathways shared in Inflammatory Bowel Disease and cervical cancer by machine learning and integrated …

TB Nguyen, DN Do, ML Nguyen-Thi… - Computers in Biology …, 2022 - Elsevier
Abstract Background Recently, Inflammatory Bowel Disease (IBD) has been proven as a risk
factor for the increasing incidence of cervical cancer (CC) development. In this study, we …

Drug resistance‐related microRNAs in osteosarcoma: Translating basic evidence into therapeutic strategies

R Chen, G Wang, Y Zheng, Y Hua… - Journal of cellular and …, 2019 - Wiley Online Library
Although the application of multiple chemotherapy brought revolutionary changes to
improve overall survival of osteosarcoma patients, the existence of multidrug resistance …

Tumor suppressor microRNA-34a inhibits cell migration and invasion by targeting MMP-2/MMP-9/FNDC3B in esophageal squamous cell carcinoma

L Yang, X Song, J Zhu, M Li, Y Ji… - International …, 2017 - spandidos-publications.com
MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in
tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of …

Genes, epigenetics and miRNA regulation in the placenta

D Vaiman - Placenta, 2017 - Elsevier
This text reviews briefly the context in which epigenetics regulate gene expression in
trophoblast development and function. It is an attempt to focus on a limited number of recent …

[HTML][HTML] MicroRNA-34a attenuates paclitaxel resistance in prostate cancer cells via direct suppression of JAG1/Notch1 axis

X Liu, X Luo, Y Wu, D Xia, W Chen, Z Fang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Treatment options for metastatic castrate-resistant prostate cancer
(mCRPC) are limited and typically centered on paclitaxel-based chemotherapy. In this study …

Roles of microRNA-34a in epithelial to mesenchymal transition, competing endogenous RNA sponging and its therapeutic potential

D Nie, J Fu, H Chen, J Cheng, J Fu - International journal of molecular …, 2019 - mdpi.com
MicroRNA-34a (miR-34a), a tumor suppressor, has been reported to be dysregulated in
various human cancers. MiR-34a is involves in certain epithelial-mesenchymal transition …

MicroRNA-34a: a versatile regulator of myriads of targets in different cancers

AA Farooqi, S Tabassum, A Ahmad - International journal of molecular …, 2017 - mdpi.com
MicroRNA-34a (miR-34a) is a tumor suppressor that has attracted considerable attention in
recent years. It modulates cancer cell invasion, metastasis, and drug resistance, and has …