Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently …

Immune checkpoint inhibitors have redefined the treatment of cancer, but their efficacy
depends critically on the presence of sufficient tumor-specific lymphocytes, and cellular …

Advancements in the field of cellular immunotherapy have accelerated in recent years and
have changed the treatment landscape for a variety of hematologic malignancies. Cellular …

Unintentional transduction of B-cell acute lymphoblastic leukemia blasts during CART19
manufacturing can lead to CAR19+ leukemic cells (CARB19) that are resistant to CART19 …

The oncolytic reovirus (RV) has demonstrated clinical efficacy and minimal toxicity in a
variety of cancers, including multiple myeloma (MM). MM is a malignancy of plasma cells …

Purpose In previous research, we have found that LMP1-specific chimeric antigen
(HELA/CAR) T cells can specifically recognize and kill LMP1-positive NPC cells. However …

Immunotherapy represents the third important wave in the history of the systemic treatment
of cancer after chemotherapy and targeted therapy and is now established as a potent and …

07 April 2023 AperTO - Archivio Istituzionale Open Access dell'Università di Torino Original
Citation: Adoptive immunotherapy w Page 1 07 April 2023 AperTO - Archivio Istituzionale Open …

Background The aim of this study was to validate the antitumor function of EGFR-chimeric
antigen T-cells (CART) targeted to FaDu cells, a hypopharyngeal squamous cell carcinoma …

BioDrugs, or advanced therapeutic medicinal products (ATMP), are novel medicines
involving genes, tissues, or cells for use in the treatment of a variety of diseases. The …