[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
Regulation of CD8+ T memory and exhaustion by the mTOR signals
Y Chen, Z Xu, H Sun, X Ouyang, Y Han, H Yu… - Cellular & Molecular …, 2023 - nature.com
CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …
Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives
The tumor microenvironment (TME) comprises a variety of immune cells, among which T
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
IS Okoye, M Houghton, L Tyrrell, K Barakat… - Frontiers in …, 2017 - frontiersin.org
In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation.
This results in expression of multiple inhibitory receptors also called “immune checkpoints” …
This results in expression of multiple inhibitory receptors also called “immune checkpoints” …
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
D Xiong, L Zhang, ZJ Sun - Military Medical Research, 2023 - Springer
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …
Modulators of MicroRNA function in the immune system
Y Jia, Y Wei - International journal of molecular sciences, 2020 - mdpi.com
MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and
responses through the negative regulation of mRNA stability and translation. The pathways …
responses through the negative regulation of mRNA stability and translation. The pathways …
Long-term persistence of exhausted CD8 T cells in chronic infection is regulated by microRNA-155
Persistent viral infections and tumors drive development of exhausted T (T EX) cells. In these
settings, T EX cells establish an important host-pathogen or host-tumor stalemate. However …
settings, T EX cells establish an important host-pathogen or host-tumor stalemate. However …
Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies
Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …
mouse studies having informed our understanding of GZMA's physiological function. We …
miR-15/16 restrain memory T cell differentiation, cell cycle, and survival
Coordinate control of T cell proliferation, survival, and differentiation are essential for host
protection from pathogens and cancer. Long-lived memory cells, whose precursors are …
protection from pathogens and cancer. Long-lived memory cells, whose precursors are …
A peptide encoded by pri‐miRNA‐31 represses autoimmunity by promoting Treg differentiation
H Zhou, F Lou, J Bai, Y Sun, W Cai, L Sun, Z Xu… - EMBO …, 2022 - embopress.org
Recent evidence has revealed that small polypeptides (containing fewer than 100 amino
acids) can be translated from noncoding RNAs (ncRNAs), which are usually defined as RNA …
acids) can be translated from noncoding RNAs (ncRNAs), which are usually defined as RNA …