The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

The emerging field of optogenetics allows for optical activation or inhibition of excitable cells.
In 2005, optogenetic proteins were expressed in the nematode Caenorhabditis elegans for …

Animals coexist in commensal, pathogenic or mutualistic relationships with complex
communities of diverse organisms, including microorganisms. Some bacteria produce …

Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is
well established that extrasynaptic volume transmission, especially via monoamines and …

Dietary composition has major effects on physiology. Here, we show that developmental
rate, reproduction, and lifespan are altered in C. elegans fed Comamonas DA1877 relative …

Since its introduction as a laboratory organism 50 years ago, the nematode worm
Caenorhabditis elegans has become one of the most widely used and versatile models for …

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric
disorders in children and adults. While ADHD patients often display circadian abnormalities …

Transmembrane channel-like (TMC) genes encode a broadly conserved family of multipass
integral membrane proteins in animals,. Human TMC1 and TMC2 genes are linked to …

Many nociceptors detect mechanical cues, but the ion channels responsible for
mechanotransduction in these sensory neurons remain obscure. Using in vivo recordings …

The effect of the detailed connectivity of a neural circuit on its function and the resulting
behavior of the organism is a key question in many neural systems. Here, we study the …