Nebulized therapies in COPD: past, present, and the future

IZ Barjaktarevic, AP Milstone - International journal of chronic …, 2020 - Taylor & Francis
Current guidelines recommend inhalation therapy as the preferred route of drug
administration for treating patients with chronic obstructive pulmonary disease (COPD) …

[HTML][HTML] The role of inspiratory flow in selection and use of inhaled therapy for patients with chronic obstructive pulmonary disease

DA Mahler - Respiratory Medicine, 2020 - Elsevier
Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management,
and inhaler selection can have a profound impact on drug delivery and medication …

Prevalence and predictors of suboptimal peak inspiratory flow rate in COPD patients

HS Harb, NI Laz, H Rabea, MEA Abdelrahim - European Journal of …, 2020 - Elsevier
The aim of this study was to determine prevalence and possible clinical predictors of
suboptimal peak inspiratory flow rate (PIFR) with different dry powder inhalers. PIFR was …

Factors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers

J WH Kocks, H Wouters, S Bosnic-Anticevich… - NPJ primary care …, 2022 - nature.com
The study aimed to determine the associations of Peak Inspiratory Flow (PIF), inhalation
technique and adherence with health status and exacerbations in participants with COPD …

Impact of PIF, inhalation technique and medication adherence on health status and exacerbations in COPD: protocol of a real-world observational study (PIFotal …

M Leving, H Wouters, A de la Hoz… - Pulmonary …, 2021 - Springer
Abstract Introduction Dry powder inhalers (DPIs), a commonly prescribed inhaler type for
respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to …

Peak inspiratory flow as a predictive therapeutic biomarker in COPD

DA Mahler, DMG Halpin - Chest, 2021 - Elsevier
Biomarkers in COPD may be clinical (prior exacerbation history), physiologic (FEV 1), or
blood based (eosinophil count or fibrinogen level). Recent interest in using biomarkers to …

Measuring peak inspiratory flow in patients with chronic obstructive pulmonary disease

JA Ohar, GT Ferguson, DA Mahler… - … journal of chronic …, 2022 - Taylor & Francis
Dry powder inhalers (DPIs) are breath actuated, and patients using DPIs need to generate
an optimal inspiratory flow during the inhalation maneuver for effective drug delivery to the …

Pharmacotherapies in older adults with COPD: challenges and opportunities

MG Matera, NA Hanania, M Maniscalco, M Cazzola - Drugs & aging, 2023 - Springer
Older adults have a higher prevalence of chronic obstructive pulmonary disease (COPD),
which will likely increase substantially in the coming decades owing to aging populations …

Prospective evaluation of exacerbations associated with suboptimal peak inspiratory flow among stable outpatients with COPD

DA Mahler, X Niu, KL Deering… - International Journal of …, 2022 - Taylor & Francis
Purpose A suboptimal peak inspiratory flow (PIF) against a dry powder inhaler (DPI) may
result in ineffective inhalation of medications, which may affect outcomes. The primary …

Relationship between peak inspiratory flow and patient and disease characteristics in individuals with COPD—a systematic scoping review

MT Leving, J Kocks, S Bosnic-Anticevich, R Dekhuijzen… - Biomedicines, 2022 - mdpi.com
Optimal delivery of medication via dry powder inhalers, the most commonly prescribed
inhaler type, is dependent on a patient achieving a minimum level of inspiratory flow during …