Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

WCC Tan, SN Nerurkar, HY Cai, HHM Ng… - Cancer …, 2020 - Wiley Online Library
Conventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue
pathology. However, this technique is associated with a number of limitations, including high …

Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in triple-negative breast cancer …

P Lotfinejad, M Asghari Jafarabadi, M Abdoli Shadbad… - Diagnostics, 2020 - mdpi.com
This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes
(TILs) and programmed death-ligand 1 (PD-L1), their associations with the …

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer

Y Qiu, Y Yang, R Yang, C Liu, JM Hsu, Z Jiang, L Sun… - Oncogene, 2021 - nature.com
Abstract Programmed cell death 1 (PD-1) is widely expressed in tumor-infiltrating
lymphocytes (TILs) of triple-negative breast cancer (TNBC). As a dominant inhibitory …

Case report: persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID

D Goh, JCT Lim, SB Fernaíndez, CR Joseph… - Frontiers in …, 2022 - frontiersin.org
The World Health Organization has defined long COVID-19 (LC) as a condition that occurs
in individuals with a history of SARS-CoV-2 infection who exhibit persistent symptoms after …

[HTML][HTML] Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular …

HHM Ng, RY Lee, S Goh, ISY Tay, X Lim… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Methods Clinically annotated samples from 49 patients with advanced HCC treated with ICB
were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex …

Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma

JY Chan, JQ Lim, J Yeong, V Ravi… - The Journal of …, 2020 - Am Soc Clin Investig
Angiosarcomas are rare, clinically aggressive tumors with limited treatment options and a
dismal prognosis. We analyzed angiosarcomas from 68 patients, integrating information …

Prognostic value and immunological role of PDCD1 gene in pan-cancer

Y Miao, J Wang, Q Li, W Quan, Y Wang, C Li… - International …, 2020 - Elsevier
Objective Identify the prognostic value and investigate the association between programmed
cell death 1 (PDCD1) gene expression and immune infiltration in pan-cancer. Methods We …

[HTML][HTML] Intratumoral CD39+ CD8+ T cells predict response to programmed cell death protein-1 or programmed death ligand-1 blockade in patients with NSCLC

J Yeong, L Suteja, Y Simoni, KW Lau, AC Tan… - Journal of Thoracic …, 2021 - Elsevier
Introduction Programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PD-
L1) blockade is currently widely used in the treatment of metastatic NSCLC. Despite …

TIM-3 as a prognostic marker and a potential immunotherapy target in human malignant tumors: a meta-analysis and bioinformatics validation

K Zang, L Hui, M Wang, Y Huang, X Zhu… - Frontiers in oncology, 2021 - frontiersin.org
Background As a novel immune checkpoint molecular, T-cell immunoglobulin mucin 3 (TIM-
3) is emerging as a therapeutic target for cancer immunotherapy. However, the predictive …

A neutrophil extracellular traps-related classification predicts prognosis and response to immunotherapy in colon cancer

C Feng, Y Li, Y Tai, W Zhang, H Wang, S Lian… - Scientific Reports, 2023 - nature.com
Neutrophil extracellular traps (NETs) have been categorized as a form of inflammatory cell
death mode of neutrophils (NETosis) involved in natural immunity and the regulation of …