Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Recent developments on other platinum metal complexes as target-specific anticancer therapeutics

TS Prathima, B Choudhury, MG Ahmad… - Coordination Chemistry …, 2023 - Elsevier
Numerous biologically active metal complexes are reported for their unique features and
enhanced functions, particularly towards the inhibition of cancer progression. With the …

Phosphorescent metal complexes as theranostic anticancer agents: combining imaging and therapy in a single molecule

CP Tan, YM Zhong, LN Ji, ZW Mao - Chemical Science, 2021 - pubs.rsc.org
Phosphorescent metal complexes are a new kind of multifunctional antitumor compounds
that can integrate imaging and antitumor functions in a single molecule. In this minireview …

Recent advances of iridium (III) metallophosphors for health-related applications

PY Ho, CL Ho, WY Wong - Coordination Chemistry Reviews, 2020 - Elsevier
Phosphorescent transition metal complexes have been intensively investigated, since these
luminophores are distinctively different from fluorescent chromophores in terms of the nature …

TEMPO in metal complex catalysis

Z Ma, KT Mahmudov, VA Aliyeva, AV Gurbanov… - Coordination Chemistry …, 2020 - Elsevier
Abstract Nitroxyl radicals, illustrated by 2, 2, 6, 6-tetramethylpiperidine-N-oxyl (TEMPO),
constitute a versatile class of stable free radicals that are extensively used in metal complex …

Delivery of Phosphorescent Anticancer Iridium (III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal …

DY Zhang, Y Zheng, H Zhang, JH Sun… - Advanced …, 2018 - Wiley Online Library
Recently, phosphorescent iridium complexes have demonstrated great potential as
anticancer and imaging agents. Dopamine is a melanin‐like mimic of mussel adhesive …

Light‐Driven Cascade Mitochondria‐to‐Nucleus Photosensitization in Cancer Cell Ablation

KN Wang, LY Liu, G Qi, XJ Chao, W Ma, Z Yu… - Advanced …, 2021 - Wiley Online Library
Nuclei and mitochondria are the only cellular organelles containing genes, which are
specific targets for efficient cancer therapy. So far, several photosensitizers have been …

Iridium (III) complexes targeting apoptotic cell death in cancer cells

DL Ma, C Wu, KJ Wu, CH Leung - Molecules, 2019 - mdpi.com
Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years,
non-platinum-based scaffolds have been exploited as viable candidates for the exploitation …

Dipyrrinato‐Iridium (III) complexes for application in photodynamic therapy and antimicrobial photodynamic inactivation

BF Hohlfeld, B Gitter, CJ Kingsbury… - … A European Journal, 2021 - Wiley Online Library
The generation of bio‐targetable photosensitizers is of utmost importance to the emerging
field of photodynamic therapy and antimicrobial (photo‐) therapy. A synthetic strategy is …

Pyriplatin-boron-dipyrromethene conjugates for imaging and mitochondria-targeted photodynamic therapy

MK Raza, S Gautam, P Howlader… - Inorganic …, 2018 - ACS Publications
Monofunctional pyriplatin analogues cis-[Pt (NH3) 2 (L) Cl](NO3)(1–3) having boron-
dipyrromethene (BODIPY) pendants (L) with 1, 3, 5, 7-tetramethyl-8-(4-pyridyl)-4, 4 …