Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

Research on the genomic architecture of speciation has increasingly revealed the
importance of structural variants (SVs) that affect the presence, abundance, position, and/or …

Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …

INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a …

There is currently little information about the evolution of gene clusters, genome
architectures and karyotypes in early branching animals. Slowly evolving anthozoan …

The zebrafish (Danio rerio) has been widely used in the study of human disease and
development, and about 70% of the protein-coding genes are conserved between the two …

Elucidating the regulatory mechanisms of human brain evolution is essential to
understanding human cognition and mental disorders. We generated multi-omics profiles …

The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Common fragile sites (CFSs) are regions susceptible to replication stress and are hotspots
for chromosomal instability in cancer. Several features were suggested to underlie CFS …