The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The mammary gland develops through several distinct stages. The first transpires in the
embryo as the ectoderm forms a mammary line that resolves into placodes. Regulated by …

We analysed primary breast cancers by genomic DNA copy number arrays, DNA
methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions
and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage
commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

The T helper lymphocyte is responsible for orchestrating the appropriate immune response
to a wide variety of pathogens. The recognition of the polarized T helper cell subsets Th1 …