Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Myocardial infarction (MI) is defined as evidence of myocardial necrosis consistent with
prolonged ischemia. In response to MI, the myocardium undergoes a series of wound …

Abstract Background and Aims Survivors of acute coronary syndromes face an elevated risk
of recurrent atherosclerosis-related vascular events despite advanced medical treatments …

Background Macrophage infiltration and polarization are integral to the progression of heart
failure and cardiac fibrosis after ischemia/reperfusion (IR). Interleukin 34 (IL-34) is an …

Sphingosine-1-phosphate (S1P) is a bioactive mediator in inflammation. Dysregulated S1P
is demonstrated as a cause of heart failure (HF). However, the time-dependent and …

In recent decades, the scientific community has seen an increased interest in rigor and
reproducibility. In 2017, concerns about methodological thoroughness and reporting …

Galectin-3 (Gal-3) is a carbohydrate-binding protein with multiple functions. Gal-3 regulates
cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions …

Inflammation presides early after myocardial infarction (MI) as a key event in cardiac wound
healing. Ischemic cardiomyocytes secrete inflammatory cues to stimulate infiltration of …

Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for
which heart transplantation remains the only definitive treatment. IHF manifests from …

Cardiovascular disease (CVD) is one of the important causes of death worldwide. The
incidence and mortality rates are increasing annually with the intensification of social aging …