[HTML][HTML] Regulation of translation initiation in eukaryotes: mechanisms and biological targets

N Sonenberg, AG Hinnebusch - Cell, 2009 - cell.com
Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Viral subversion of the host protein synthesis machinery

D Walsh, I Mohr - Nature Reviews Microbiology, 2011 - nature.com
Viruses are fully reliant on the translation machinery of their host cells to produce the
polypeptides that are essential for viral replication. Consequently, viruses recruit host …

KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and …

C Arias, B Weisburd, N Stern-Ginossar… - PLoS …, 2014 - journals.plos.org
Productive herpesvirus infection requires a profound, time-controlled remodeling of the viral
transcriptome and proteome. To gain insights into the genomic architecture and gene …

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

M Shuda, HJ Kwun, H Feng, Y Chang… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …

Translational control in virus-infected cells

N Stern-Ginossar, SR Thompson… - Cold Spring …, 2019 - cshperspectives.cshlp.org
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …

Tinkering with translation: protein synthesis in virus-infected cells

D Walsh, MB Mathews, I Mohr - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Viruses are obligate intracellular parasites, and their replication requires host cell functions.
Although the size, composition, complexity, and functions encoded by their genomes are …

A cap-to-tail guide to mRNA translation strategies in virus-infected cells

E Jan, I Mohr, D Walsh - Annual review of virology, 2016 - annualreviews.org
Although viruses require cellular functions to replicate, their absolute dependence upon the
host translation machinery to produce polypeptides indispensable for their reproduction is …

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

U Chuluunbaatar, R Roller, ME Feldman… - Genes & …, 2010 - genesdev.cshlp.org
All viruses require cellular ribosomes to translate their mRNAs. Viruses producing methyl-7
(m7) GTP-capped mRNAs, like Herpes Simplex Virus-1 (HSV-1), stimulate cap-dependent …

The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycle

S Rajendren, X Ye, W Dunker, A Richardson… - Nature …, 2023 - nature.com
Adenosine-to-inosine RNA editing is a major contributor to transcriptome diversity in animals
with far-reaching biological consequences. Kaposi's sarcoma-associated herpesvirus …

A viral nuclear noncoding RNA binds re-localized poly (A) binding protein and is required for late KSHV gene expression

S Borah, N Darricarrère, A Darnell, J Myoung… - PLoS …, 2011 - journals.plos.org
During the lytic phase of infection, the gamma herpesvirus K aposi's S arcoma-Associated H
erpes v irus (KSHV) expresses a highly abundant, 1.1 kb nuclear noncoding RNA of …