Acetyl-CoA metabolism in cancer
DA Guertin, KE Wellen - Nature Reviews Cancer, 2023 - nature.com
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …
A global view of the human post-translational modification landscape
N Kitamura, JJ Galligan - Biochemical Journal, 2023 - portlandpress.com
Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …
metabolism and gene expression and maintain homeostasis. Advances in mass …
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer
Acetate metabolism is an important metabolic pathway in many cancers and is controlled by
acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to …
acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to …
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
LT Izzo, S Trefely, C Demetriadou, JM Drummond… - Science …, 2023 - science.org
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease
Y Lin, A Lin, L Cai, W Huang, S Yan, Y Wei… - Molecular …, 2023 - Springer
Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …
ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …
remains elusive, hindering the development of novel therapeutics. In this study, we used …
Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression
Post-translational modifications (PTMs) on histones are a key source of regulation on
chromatin through impacting cellular processes, including gene expression. These PTMs …
chromatin through impacting cellular processes, including gene expression. These PTMs …
Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation
DC Alexander, T Corman, M Mendoza… - Proceedings of the …, 2022 - National Acad Sciences
Histone acetylation is a key component in the consolidation of long-term fear memories.
Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear …
Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear …
Metabolic modulation of transcription: The role of one-carbon metabolism
While it is well known that expression levels of metabolic enzymes regulate the metabolic
state of the cell, there is mounting evidence that the converse is also true, that metabolite …
state of the cell, there is mounting evidence that the converse is also true, that metabolite …
Dynamic protein deacetylation is a limited carbon source for acetyl-CoA–dependent metabolism
The ability of cells to store and rapidly mobilize energy reserves in response to nutrient
availability is essential for survival. Breakdown of carbon stores produces acetyl-CoA …
availability is essential for survival. Breakdown of carbon stores produces acetyl-CoA …