The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing
materials to support tissue repair and regeneration. Despite the many biomaterial …

All biomaterials, when implanted in vivo, elicit cellular and tissue responses. These
responses include the inflammatory and wound healing responses, foreign body reactions …

The healing process after implantation of biomaterials involves the interaction of many
contributing factors. Besides their in vivo functionality, biomaterials also require …

The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts
and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both …

The ability to monitor diseases, therapies, and their effects on the body is a critical
component of modern care and personalized medicine. Real time monitoring can be …

The word “biocompatibility,” is inconsistent with the observations of healing for so‐called
biocompatible biomaterials. The vast majority of the millions of medical implants in humans …

It is widely known that bone has intrinsic capacity to self-regenerate after injury. However,
the physiological regeneration process can be impaired when there is an extensive …

In pelvic organ prolapse (POP) patients, the uterus, bladder and/or rectum descends into
vagina due to weakened support tissues. High recurrence rates after POP surgery suggest …

The role of endogenous bile acids as lipid stabilizers aiding uptake of lipophilic nutrients via
micelle formation and saponification effects is well documented and precedes their growing …