Background Volatile agents alter inhibitory postsynaptic currents (IPSCs) at clinically
relevant concentrations, an action that is thought to make an important contribution to their …

Background A relatively small number of inhibitory interneurons can control the excitability
and synchronization of large numbers of pyramidal cells in hippocampus and other cortical …

Background: Effects of volatile anesthetic agents on N-meth-yl-D-aspartate (NMDA) receptor–
mediated excitatory synaptic transmission have not been well characterized. The authors …

BACKGROUND: Anesthetics enhance γ-aminobutyric acid (GABA)-mediated inhibition in
the central nervous system. Different agents have been shown to act on tonic versus …

Background Anesthesia is produced by a depression of central nervous system function,
however, the sites and mechanisms of action underlying this depression remain poorly …

A relatively small number of inhibitory interneurons can control the excitability and
synchronization of large numbers of pyramidal neurons in hippocampus and other cortical …

Cell–cell communication via gap junction channels is known to be inhibited by the
anesthetics heptanol, halothane and isoflurane; however, despite numerous studies, the …

Background Anesthetic-induced CNS depression is thought to involve reduction of
glutamate release from nerve terminals. Recent studies suggest that isoflurane reduces …

General anesthetics are thought to depress the central nervous system (CNS) by acting at
synapses; however, only a few studies have compared effects on axonal conduction with …

BACKGROUND: Anesthesia is produced by a depression of neuronal signaling in the
central nervous system (CNS); however, the mechanism (s) of action underlying this …