Mucosal immune responses to respiratory syncytial virus

MVC Barnes, PJM Openshaw, RS Thwaites - Cells, 2022 - mdpi.com
Despite over half a century of research, respiratory syncytial virus (RSV)-induced
bronchiolitis remains a major cause of hospitalisation in infancy, while vaccines and specific …

Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review

SB Besteman, D Bogaert, L Bont, A Mejias… - The Lancet …, 2024 - thelancet.com
Lower respiratory tract infections, commonly caused by respiratory syncytial virus (RSV) or
Streptococcus pneumoniae (pneumococcus), pose a substantial global health burden …

Unique microbial landscape in the human oropharynx during different types of acute respiratory tract infections

H Li, X Wu, H Zeng, B Chang, Y Cui, J Zhang, R Wang… - Microbiome, 2023 - Springer
Background Secondary bacterial infections and pneumonia are major mortality causes of
respiratory viruses, and the disruption of the upper respiratory tract (URT) microbiota is a …

[HTML][HTML] Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α

AR Owen, A Farias, AM Levins, Z Wang, SL Higham… - Mucosal …, 2024 - Elsevier
Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections.
Understanding why some individuals get more serious disease may help with diagnosis and …

Nasopharyngeal Codetection of Haemophilus influenzae and Streptococcus pneumoniae Shapes Respiratory Syncytial Virus Disease Outcomes in Children

A Diaz-Diaz, E Bunsow… - The Journal of …, 2022 - academic.oup.com
Background The role of nasopharyngeal bacteria in respiratory syncytial virus (RSV)
disease has been underestimated. We measured the frequency and burden of respiratory …

[HTML][HTML] Long-term respiratory consequences of early-life respiratory viral infections: a pragmatic approach to fundamental questions

NB Achten, AMC van Rossum, LB Bacharier… - The Journal of Allergy …, 2022 - Elsevier
Early-life viral infection can have profound effects on the developing lung and immune
systems, both important in asthma development. For decades, research has aimed to …

Respiratory and Gut Microbiome Modification during respiratory syncytial virus infection: a systematic review

K Yagi, NW Lukacs, GB Huffnagle, H Kato, N Asai - Viruses, 2024 - mdpi.com
Background: Respiratory syncytial virus (RSV) infection is a major cause of lower respiratory
tract infection, especially in infants, and increases the risk of recurrent wheezing and …

Microbiota as a potentially-modifiable factor influencing COVID-19

VL Ngo, AT Gewirtz - Current Opinion in Virology, 2021 - Elsevier
Impacts of respiratory tract viruses have long been appreciated to highly heterogeneous
both between and within various populations. The SARS-CoV-2 pandemic, which is the first …

Alterations of the Mucosal Immune Response and Microbial Community of the Skin upon Viral Infection in Rainbow Trout (Oncorhynchus mykiss)

M Zhan, Z Huang, G Cheng, Y Yu, J Su… - International Journal of …, 2022 - mdpi.com
The skin is the largest organ on the surface of vertebrates, which not only acts as the first line
of defense against pathogens but also harbors diverse symbiotic microorganisms. The …

Airway gene expression correlates of respiratory syncytial virus disease severity and microbiome composition in infants

CY Chu, X Qiu, MN McCall, L Wang… - The Journal of …, 2021 - academic.oup.com
Background Respiratory syncytial virus (RSV) is the leading cause of severe respiratory
disease in infants. The causes and correlates of severe illness in the majority of infants are …