[HTML][HTML] HIF-1α pathway: role, regulation and intervention for cancer therapy
GN Masoud, W Li - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …
drug target. Many recent studies have provided convincing evidences of strong correlation …
[HTML][HTML] Activation of AMPK under hypoxia: many roads leading to Rome
F Dengler - International journal of molecular sciences, 2020 - mdpi.com
AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …
mediating the adaptation to low energy levels by deactivating anabolic processes and …
Hypoxia-induced angiogenesis: good and evil
BL Krock, N Skuli, MC Simon - Genes & cancer, 2011 - journals.sagepub.com
The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …
therefore not surprising that O2 availability serves as a primary regulator of this complex …
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
Hypoxia-inducible factor-1 (HIF-1)
Q Ke, M Costa - Molecular pharmacology, 2006 - ASPET
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …
Physiological and pathological responses to hypoxia
C Michiels - The American journal of pathology, 2004 - Elsevier
As the average age in many countries steadily rises, heart infarction, stroke, and cancer
become the most common causes of death in the 21st century. The causes of these …
become the most common causes of death in the 21st century. The causes of these …
Oxygen in wound healing—more than a nutrient
AA Tandara, TA Mustoe - World journal of surgery, 2004 - Springer
This article provides an overview of the role of oxygen in wound healing. The understanding
of this role has undergone a major evolution from its long-recognized importance as an …
of this role has undergone a major evolution from its long-recognized importance as an …
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
J Ye - International journal of obesity, 2009 - nature.com
Recent studies consistently support a hypoxia response in the adipose tissue in obese
animals. The observations have led to the formation of an exciting concept, adipose tissue …
animals. The observations have led to the formation of an exciting concept, adipose tissue …
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
The role of low-grade inflammation in the polycystic ovary syndrome
A Repaci, A Gambineri, R Pasquali - Molecular and cellular endocrinology, 2011 - Elsevier
PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …