Simple Summary Patients with cancer of unknown primary site suffer the burden of an
uncertain disease, which is characterized by the impossibility to identify the tissue where the …

Background Although the incidence of Cancer of Unknown Primary (CUP) is estimated to be
1–2% of all cancers worldwide, no international standards for diagnostic workup are yet …

Metastatic uveal melanoma is less well understood than its primary counterpart, has a
distinct biology compared to skin melanoma, and lacks effective treatments. Here we …

Simple Summary CAR-T cells are immune cells equipped with a claw that enable them to
bind cancer cells. Usually, CAR-T cells are made using immune cells from blood. Here, we …

The accurate identification of tissue origin in patients with metastatic cancer is critical for
effective treatment selection but remains a challenge. The aim of this study is to develop a …

Despite recent improvements in cancer diagnostics, 2%-5% of all malignancies are still
cancers of unknown primary (CUP), for which the tissue-of-origin (TOO) cannot be …

Background Cancer of unknown primary (CUP) is a malignant and aggressive tumor whose
primary origin is still unknown despite thorough evaluation. CUP can be life-threatening with …

Background and Aims Pancreatic cancer is the seventh leading cause of cancer-related
deaths worldwide. Checkpoint immunotherapy has not yet shown encouraging results in …

To the Editor—We read with great interest the recent paper1 by Alvarez et al. In it, they use
the VIPER algorithm2 to mine transcriptome data from 212 rare gastroentero-pancreatic …

Uveal melanoma (UM) is a rare form of melanoma with a genetics and immunology that is
different from skin melanoma. Previous studies have identified genetic driver events of early …