Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

X He, X Chen, Y Yang, Y Xie, Y Liu - Journal of ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Epilepsy is a neurological disorder that presents with
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …

[HTML][HTML] Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression …

S Javaid, F Alqahtani, W Ashraf, SMM Anjum… - Biomedicine & …, 2023 - Elsevier
Abstract Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic
signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic …

Challenges and discoveries in polypharmacology of neurodegenerative diseases

TCM Lustoza Rodrigues, NF de Sousa… - Current Topics in …, 2023 - ingentaconnect.com
Background: Neurological disorders are composed of several diseases that affect the central
and peripheral nervous system; among these are neurodegenerative diseases, which lead …

Rutin-loaded selenium nanoparticles modulated the redox status, inflammatory, and apoptotic pathways associated with pentylenetetrazole-induced epilepsy in mice

KM Mohamed, MS Abdelfattah… - Green Processing and …, 2023 - degruyter.com
Worldwide, epilepsy is the second most prevalent neurological disorder. Disappointingly,
various adverse effects are being observed with currently used antiepileptic drugs …

Impact of Saussurea lappa root extract against copper oxide nanoparticles induced oxidative stress and toxicity in rat cardiac tissues

E Tousson, DM El‐Gharbawy - Environmental Toxicology, 2023 - Wiley Online Library
Abstract Copper oxide nanoparticles (CuO NPs) have developed as a significant class of
nanomaterial with potential dangers to organisms and the environment in a variety of …

[HTML][HTML] Role of oral supplementation of damiana (Turnera diffusa) reduces the renal toxicity, apoptosis and DNA damage associated with amitriptyline administration …

AF Hasan, HM Hameed, E Tousson… - Biomedical and …, 2022 - biomedpharmajournal.org
Major depressive disorder and anxiety disorders are two mental diseases that are treated
with amitriptyline (AMT). AMT treatments induced liver, heart and testes toxicity; As a result …

Alzheimer's disease‐related brain insulin resistance and the prospective therapeutic impact of metformin

HA Abosharaf, Y Elsonbaty, E Tousson… - Journal of …, 2024 - Wiley Online Library
Besides COVID‐19, two of the most critical outbreaks of our day are insulin resistance, type
2 diabetes mellitus (T2DM), and Alzheimer's disease (AD). Each disease's pathophysiology …

Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms

A Essawy, S Matar, N Mohamed… - … Science and Pollution …, 2024 - Springer
The use of additives, especially colorants, in food and pharmaceutical industry is increasing
dramatically. Currently, additives are classified as contaminants of emerging concern …

Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish

R Chitolina, CG Reis, T Stahlhofer-Buss… - Pharmacological …, 2023 - Springer
Background Epilepsy is a prevalent neurological disease, affecting approximately 1–2% of
the global population. The hallmark of epilepsy is the occurrence of epileptic seizures, which …

[HTML][HTML] Anti-diabetic effects of pomegranate peel extract and L-carnitine on streptozotocin induced diabetes in rats

AMM Ezz, S Zaki, GA Tabl - … and Pharmacology Journal, 2023 - biomedpharmajournal.org
Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by
hyperglycemia and related with a few intricacies like hyperlipidemia. The current study …