Recent progress in the identification of early transition biomarkers from relapsing-remitting to progressive multiple sclerosis

S Maier, L Barcutean, S Andone, D Manu… - International Journal of …, 2023 - mdpi.com
Despite extensive research into the pathophysiology of multiple sclerosis (MS) and recent
developments in potent disease-modifying therapies (DMTs), two-thirds of relapsing …

Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology

IN Petropoulos, G Bitirgen, M Ferdousi… - Frontiers in Pain …, 2021 - frontiersin.org
Neuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or
damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging …

Recovery of corneal innervation after treatment in dry eye disease: a confocal microscopy study

A Barros, J Lozano-Sanroma… - Journal of Clinical …, 2023 - mdpi.com
Purpose: To analyze the changes in corneal innervation by means of in vivo corneal
confocal microscopy (IVCM) in patients diagnosed with Evaporative (EDE) and Aqueous …

[HTML][HTML] Abnormal dynamic pupillometry relates to neurologic disability and retinal axonal loss in patients with multiple sclerosis

G Bitirgen, Z Akpinar, HB Turk… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: To assess alterations in quantitative dynamic pupil responses to light in relation to
neurologic disability and retinal axonal loss in patients with multiple sclerosis (MS) …

Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers

A Suh, G Hampel, A Vinjamuri, J Ong, SA Kamran… - Eye, 2024 - nature.com
Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central
nervous system (CNS) characterized by inflammation, demyelination, and axonal damage …

Corneal axonal loss as an imaging biomarker of neurodegeneration in multiple sclerosis: a longitudinal study

IN Petropoulos, F Al-Shibani… - Therapeutic …, 2023 - journals.sagepub.com
Background: Resourceful endpoints of axonal loss are needed to predict the course of
multiple sclerosis (MS). Corneal confocal microscopy (CCM) can detect axonal loss in …

Corneal immune cells as a biomarker of inflammation in multiple sclerosis: a longitudinal study

IN Petropoulos, K John, F Al-Shibani… - Therapeutic …, 2023 - journals.sagepub.com
Background: Corneal immune cells (ICs) are antigen-presenting cells that are known to
increase ocular and systemic inflammatory conditions. Objective: We aimed to assess …

Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation

J Oh, L Airas, D Harrison, E Järvinen… - Frontiers in …, 2023 - frontiersin.org
Key unmet needs in multiple sclerosis (MS) include detection of early pathology, disability
worsening independent of relapses, and accurate monitoring of treatment response …

The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson's disease

NN Che, QH Jiang, S Chen, SY Chen… - Therapeutic …, 2023 - journals.sagepub.com
Background: Parkinson's disease (PD) is a heterogeneous movement disorder with patients
manifesting with either tremor-dominant (TD) or postural instability and gait disturbance …

[HTML][HTML] Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

IN Petropoulos, KE Aly, S Al-Thani… - … Vision Science & …, 2024 - iovs.arvojournals.org
Purpose: To assess whether corneal nerve analysis can identify and differentiate patients
with multiple sclerosis (MS) from those with epilepsy. Methods: Participants with MS (n= 83) …