Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Background Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma)
often has a devastating outcome. We compared myeloablative CD34+ selected autologous …

In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Rationale: Umbilical cord–derived mesenchymal stem cells (UC-MSC) are easily accessible
and expanded in vitro, possess distinct properties, and improve myocardial remodeling and …

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy
have been assessed in several clinical trials. These trials can be categorized as those using …

The win ratio was introduced in 2012 as a new method for examining composite endpoints
and has since been widely adopted in cardiovascular (CV) trials. Improving upon …

Although it is a rare disease, the number of available therapeutic options for treating
pulmonary arterial hypertension has increased since the late 1990s, with multiple drugs …