A multilayered immune system through the lens of unconventional T cells
The unconventional T cell compartment encompasses a variety of cell subsets that straddle
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
PJ Brennan, M Brigl, MB Brenner - Nature Reviews Immunology, 2013 - nature.com
Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
ILC1 confer early host protection at initial sites of viral infection
Infection is restrained by the concerted activation of tissue-resident and circulating immune
cells. Whether tissue-resident lymphocytes confer early antiviral immunity at local sites of …
cells. Whether tissue-resident lymphocytes confer early antiviral immunity at local sites of …
Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection
M Brigl, RVV Tatituri, GFM Watts, V Bhowruth… - Journal of Experimental …, 2011 - rupress.org
Invariant natural killer T cells (iNKT cells) are critical for host defense against a variety of
microbial pathogens. However, the central question of how iNKT cells are activated by …
microbial pathogens. However, the central question of how iNKT cells are activated by …
[HTML][HTML] Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
A Kurioka, P Klenerman - Seminars in Immunology, 2023 - Elsevier
Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages
Invariant natural killer T (iNKT) cells are non-conventional lipid-reactive αβ T lymphocytes
that play a key role in host responses during viral infections, in particular through the swift …
that play a key role in host responses during viral infections, in particular through the swift …
Regulation of NKT cell localization in homeostasis and infection
D Slauenwhite, B Johnston - Frontiers in immunology, 2015 - frontiersin.org
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune
responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens …
responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens …
Insights into mucosal-associated invariant T cell biology from studies of invariant natural killer T cells
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are
innate-like T cells that function at the interface between innate and adaptive immunity. They …
innate-like T cells that function at the interface between innate and adaptive immunity. They …
Activation and function of iNKT and MAIT cells
S Chandra, M Kronenberg - Advances in immunology, 2015 - Elsevier
Over the last two decades, it has been established that peptides are not the only antigens
recognized by T lymphocytes. Here, we review information on two T lymphocyte populations …
recognized by T lymphocytes. Here, we review information on two T lymphocyte populations …